Are two birds in the hand worth one in the bush?

What if it's a really big bird in the bush?

I mentioned earlier that I have two upcoming first-round interviews.  Yesterday, I e-mailed my application for a job that, based on its description, would suit me very well:  grounds manager at a college in California.  So, then, what if one of the two interview companies wants me?  Do I accept because it's an offer and I need a job, or do I hold out in the hopes that the job that I like likes me as well?  And then if they don't want me, I'm stuck, right?